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Hypersensitivity to the active substances, to dihydropyridine derivatives, or to any of the excipients Severe hepatic impairment, biliary cirrhosis or cholestasis.
Severe renal impairment (glomerular filtration rate (GFR) <30 ml/min/1.73 m2) and patients undergoing dialysis. Second and third trimesters of pregnancy.
Severe hypotension.
Shock (including cardiogenic shock).
Obstruction of the outflow tract of the left ventricle (e.g. hypertrophic obstructive cardiomyopathy and high grade aortic stenosis).
Haemodynamically unstable heart failure after acute myocardial infarction.
